Boerhavia diffusa L. ethanol extract suppresses inflammatory responses via inhibition of Src/Syk/TRAF6
作者: Ha Van ThaiEunji KimSeung Cheol KimDeok JeongSungjae YangKwang-Soo BaekYong KimZubair Ahmed RatanKee Dong YoonJong-Hoon KimJae Youl Cho
作者单位: 1Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, South Korea
2Division of Gynecologic Oncology Department of Obstetrics and Gynecology, Ewha Womans University Mokdong Hospital College of Medicine, Ewha Womans University, Seoul 158-710, South Korea
3College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, South Korea
4Department of Veterinary Physiology, College of Veterinary Medicine, Biosafety Research Institute, Chonbuk National University, Jeonju 561-756, South Korea
刊名: Journal of Functional Foods, 2015, Vol.17 , pp.476-490
来源数据库: Elsevier Journal
DOI: 10.1016/j.jff.2015.06.004
关键词: Boerhavia diffusa L. (Phyllanthaceae)Anti-inflammatory effectSrcSykTRAF6Luteolin
原始语种摘要: Abstract(#br)Boerhavia diffusa L. is a green vegetable used as an herbal medicine in several Asian countries for the treatment of hepatitis, kidney stones, liver disorders, nephritis, urinary disorders, and urinary retention. In this study, the anti-inflammatory activity and the molecular inhibitory mechanisms of B. diffusa L. ethanol extract (Bd-EE) in vitro and in vivo were evaluated. Lipopolysaccharide (LPS)-activated peritoneal macrophage RAW264.7 cells and a mouse gastritis model induced by HCl/EtOH treatment were chosen to determine the in vitro and in vivo anti-inflammatory activities of Bd-EE. This extract (100 and 200 µg/ml) significantly ( P < 0.01) inhibited nitric oxide (NO) and tumour necrosis factor (TNF)-α production in peritoneal macrophages and in RAW264.7 cells during...
全文获取路径: Elsevier  (合作)
影响因子:2.632 (2012)

  • inflammatory 激怒的
  • extract 提取
  • ethanol 乙醇
  • inhibition 抑制
  • macrophages 巨噬细胞
  • nitric 氮的
  • urinary 尿的
  • luteolin 黄色素
  • peritoneal 腹膜的
  • inhibited 被禁止