Protective mechanism of Eucommia ulmoids flavone (EUF) on enterocyte damage induced by LPS
作者: Tarique HussainBie TanNajma RahuDildar Hussain KalhoroRahim DadYulong Yin
作者单位: 1The Chinese Academy of Sciences, China, People's Republic of China
2Department of Veterinary Microbiology, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tando Jam, Sindh 70050, Pakistan
3Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Education Ministry of China, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China
刊名: Free Radical Biology and Medicine, 2017, Vol.108 , pp.S40-S40
来源数据库: Elsevier Journal
DOI: 10.1016/j.freeradbiomed.2017.04.152
关键词: Eucommia ulmoids flavoneInflammationEnterocytes and LPS
原始语种摘要: The study was carried out to explore the anti-oxidative properties of Eucommia ulmoids flavone. IPEC-J2 cells was cultured in DMEM medium containing 0, 10µg/ml EUF, 0, 40ng/ml LPS and 0 or 10μmol/L LY29400 (PI3K inhibitor) for 2 days. The results reveal that LPS decrease DNA synthesis (P<0.05) and viable number of cells (P<0.05) arrest cell cycle at S-phase and induce apoptosis (P<0.05), influence mitochondrial function (P<0.05), decrease SOD activity, polyamine capacity (P<0.05) and induce inflammation by phosphorylation of p-IKKα/β and p-NF-KB pathways (P<0.05). In addition, Eucommia ulmoids flavone, confirms beneficial effects on DNA synthesis, cell viability, mitochondrial function, SOD activity and polyamine capacity (P<0.05). This action proved by activation of...
全文获取路径: Elsevier  (合作)
影响因子:5.271 (2012)

  • flavone 黄酮
  • EUF End User Facility
  • LPS Laboratory Peripheral System
  • enterocyte 肠上皮细胞
  • induced 感应的
  • mechanism 机构
  • mitochondrial 线粒体的
  • damage 损伤
  • SOD Superintendent Of Documents
  • inhibiting 抑制