Increased circulating sclerostin levels in end-stage renal disease predict biopsy-verified vascular medial calcification and coronary artery calcification
作者: Abdul Rashid QureshiHannes OlausonAnna WitaspMathias HaarhausVincent BrandenburgAnnika WernersonBengt LindholmMagnus SöderbergLars WennbergLouise NordforsJonaz RipswedenPeter BaranyPeter Stenvinkel
作者单位: 1Division of Renal Medicine and Baxter Novum, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
2Department of Cardiology, University Hospital RWTH Aachen, Aachen, Germany
3Pathology, Drug Safety and Metabolism, AstraZeneca, Mölndal, Sweden
4Division of Transplantation Surgery, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
5Division of Radiology, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
刊名: Kidney International, 2015, Vol.88 (6), pp.1356-1364
来源数据库: Elsevier Journal
DOI: 10.1038/ki.2015.194
关键词: end-stage renal diseaseinflammationmineral-bone diseasesclerostinvascular calcification
原始语种摘要: Sclerostin, an osteocyte-derived inhibitor of bone formation, is linked to mineral bone disorder. In order to validate its potential as a predictor of vascular calcification, we explored associations of circulating sclerostin with measures of calcification in 89 epigastric artery biopsies from patients with end-stage renal disease. Significantly higher sclerostin levels were found in the serum of patients with epigastric and coronary artery calcification (calcification score 100 or more). In Spearman’s rank correlations, sclerostin levels significantly associated with age, intact parathyroid hormone, bone-specific alkaline phosphatase, and percent calcification. Multivariable regression showed that age, male gender, and sclerostin each significantly associated with the presence of medial...
全文获取路径: Elsevier  (合作)
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影响因子:7.916 (2012)

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关键词翻译
关键词翻译
  • calcification 钙化
  • renal 肾的
  • vascular 维管的
  • coronary 冠状的
  • circulating 循环
  • associated 相关的
  • artery 动脉
  • epigastric 腹上部的
  • stage 
  • predict 预见