Vitamin D-induced ectodomain shedding of TNF receptor 1 as a nongenomic action: D 3 vs D 2 derivatives
作者: Won Seok YangHoon YuJin Ju KimMee Jeong LeeSu-Kil Park
作者单位: 1Division of Nephrology, Department of Internal Medicine, Asan Medical Center, College of Medicine, University of Ulsan, 88 Olympic-Ro 43-Gil, SongPa-Gu, Seoul 138-736, Republic of Korea
2Asan Institute for Life Sciences, 88 Olympic-Ro 43-Gil, SongPa-Gu, Seoul 138-736, Republic of Korea
3Department of Pediatrics, College of Medicine, Dankook University, Anseo-dong San 16-5, Cheonan, Chungcheongnam-do 330-715, Republic of Korea
刊名: Journal of Steroid Biochemistry and Molecular Biology, 2016, Vol.155 , pp.18-25
来源数据库: Elsevier Journal
DOI: 10.1016/j.jsbmb.2015.09.019
关键词: ADAM10125-Dihydroxyvitamin D 225-Hydroxyvitamin D 3ERp57L-type Ca 2+ channelTNF receptor 1
原始语种摘要: Abstract(#br)As a nongenomic action, 1,25-dihydroxyvitamin D 3 (1,25D 3 ) induces L-type Ca 2+ channel-mediated extracellular Ca 2+ influx in human aortic smooth muscle cells (HASMCs), which activates a disintegrin and metalloprotease 10 (ADAM10) to cleave and shed the ectodomain of tumor necrosis factor receptor 1 (TNFR1). In this study, we examined the potencies of other vitamin D 3 and D 2 analogs to stimulate the ectodomain shedding of TNFR1 in HASMCs.(#br)25-Hydroxyvitamin D 3 (25D 3 ), a precursor of 1,25D 3 , and elocalcitol, an analog of 1,25D 3 , caused ectodomain shedding of TNFR1 within 30min, whereas 1,25-dihydroxyvitamin D 2 (1,25D 2 ) and paricalcitol, a derivative of 1,25D 2 , did not. Both 25D 3 and elocalcitol rapidly induced extracellular Ca 2+ influx...
全文获取路径: Elsevier  (合作)
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关键词翻译
关键词翻译
  • receptor 接受体
  • induced 感应的
  • shedding 脱落
  • translocation 移位
  • vitamin 维生素
  • verapamil 维拉帕米
  • cleave 劈开解理
  • stimulate 刺激
  • intracellular 胞内的
  • extracellular 胞外的