Protein aggregation, cardiovascular diseases, and exercise training: Where do we stand?
作者: Marisol GouveiaKe XiaWilfredo ColónSandra I. VieiraFernando Ribeiro
作者单位: 1Department of Medical Sciences and Institute of Biomedicine – iBiMED, University of Aveiro, Aveiro, Portugal
2Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, USA
3School of Health Sciences and Institute of Biomedicine – iBiMED, University of Aveiro, Aveiro, Portugal
刊名: Ageing Research Reviews, 2017, Vol.40 , pp.1-10
来源数据库: Elsevier Journal
DOI: 10.1016/j.arr.2017.07.005
关键词: Protein aggregationProteostasisAgingCardiovascular diseasesExercise
原始语种摘要: Abstract(#br)Cells ensure their protein quality control through the proteostasis network. Aging and age-related diseases, such as neurodegenerative and cardiovascular diseases, have been associated to the reduction of proteostasis network efficiency and, consequently, to the accumulation of protein misfolded aggregates. The decline in protein homeostasis has been associated with the development and progression of atherosclerotic cardiovascular disease, cardiac hypertrophy, cardiomyopathies, and heart failure. Exercise training is a key component of the management of patients with cardiovascular disease, consistently improving quality of life and prognosis. In this review, we give an overview on age-related protein aggregation, the role of the increase of misfolded protein aggregates on...
全文获取路径: Elsevier  (合作)
影响因子:5.953 (2012)

  • exercise 练习
  • cardiovascular 心血管的
  • aggregation 聚集
  • protein 蛋白质
  • training 培养
  • intervention 
  • associated 相关的
  • hypertrophy 肥大
  • homeostasis 体内平衡
  • deleterious 有害的