Pathological roles of the homeostatic chemokine CXCL12
作者: Rik JanssensSofie StruyfPaul Proost
作者单位: 1KU Leuven, University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Immunology, B-3000 Leuven, Belgium
刊名: Cytokine and Growth Factor Reviews, 2018
来源数据库: Elsevier Journal
DOI: 10.1016/j.cytogfr.2018.10.004
关键词: CXCL12Stromal cell-derived factorChemokineCXCR4ACKR3Leukocyte migration
原始语种摘要: Abstract(#br)CXCL12 is a CXC chemokine that traditionally has been classified as a homeostatic chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis and angiogenesis. In contrast to these homeostatic functions, increased expression of CXCL12 in general, or of a specific CXCL12 splicing variant has been demonstrated in various pathologies. In addition to this increased or differential transcription of CXCL12, also upregulation of its receptors CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) contributes to the onset or progression of diseases. Moreover, posttranslational modification of CXCL12 during disease progression, through interaction with locally produced molecules or enzymes, also affects CXCL12 activity, adding further...
全文获取路径: Elsevier  (合作)
影响因子:8.831 (2012)

  • homeostatic 恒定性的
  • receptor 接受体
  • neutralizing 中和
  • osteoarthritis 骨关节炎
  • crucial 有决定性的
  • transcription 地名转写
  • molecule 分子
  • splicing 接合
  • demonstrated 探明的储量
  • broadly 概括地