Multicellular scale front-to-rear polarity in collective migration
作者: Lavinia CapuanaAstrid BoströmSandrine Etienne-Manneville
作者单位: 1Cell Polarity, Migration and Cancer Unit, Institut Pasteur, UMR3691 CNRS, Équipe Labellisée Ligue Contre le Cancer, F-75015, Paris, France
2Sorbonne Université, Collège Doctoral, F-75005 Paris, France
3School of Life Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK
刊名: Current Opinion in Cell Biology, 2020, Vol.62 , pp.114-122
来源数据库: Elsevier Journal
DOI: 10.1016/
关键词: MigrationPolarityChemotaxisDurotaxisAdherens junctionsRho GTPaseBorder cellsNeural crestEpithelial cells
英文摘要: Abstract(#br)Collective cell migration does not only reflect the migration of cells at a similar speed and in the same direction, it also implies the emergence of new properties observed at the level of the cell group. This collective behavior relies on interactions between the cells and the establishment of a hierarchy amongst cells with leaders driving the group of followers. Here, we make the parallel between the front-to-rear polarity axis in single cell and the front-to-rear multicellular-scale polarity of a migrating collective which established through exchange of biochemical and mechanical information from the front to the rear and vice versa. Such multicellular-scale polarity gives the migrating group the possibility to better sense and adapt to energy, biochemical and mechanical...
全文获取路径: Elsevier  (合作)
影响因子:11.41 (2012)

  • migration 迁移
  • polarity 极性
  • front 工祖
  • scale 度盘
  • collective 集体