Effects of carboplatin on amino acid chemistry in chinchilla cochlear nucleus
作者: Yingzhe LiDonald A. GodfreyMatthew A. GodfreyDa-lian DingRichard Salvi
作者单位: 1Department of Otolaryngology – Head and Neck Surgery, Medical College of Ohio, 3065 Arlington Avenue, Toledo, OH 43614, USA
2Center for Hearing and Deafness, University of Buffalo, Buffalo, NY 14214, USA
刊名: Hearing Research, 2002, Vol.165 (1), pp.19-29
来源数据库: Elsevier Journal
DOI: 10.1016/S0378-5955(01)00389-6
关键词: AuditoryOtotoxicityAspartateGlutamateγ-AminobutyrateGlycineGlutaminase
原始语种摘要: Abstract(#br)Carboplatin, a drug widely used against solid head and neck tumors, selectively destroys cochlear inner hair cells and type I auditory nerve fibers in chinchilla. This should affect neurotransmitter chemistry, involving amino acids, where the type I auditory nerve fibers terminate in the cochlear nucleus. Using microdissection combined with high-performance liquid chromatography, amino acid concentrations were mapped in the cochlear nuclei of chinchillas injected intraperitoneally 6–8 weeks earlier with 100 mg/kg carboplatin and in those of control animals. Glutamate concentrations were 23% lower in the anteroventral cochlear nucleus (AVCN) and 40% lower in the posteroventral cochlear nucleus (PVCN) of carboplatin-injected chinchillas as compared to controls, while aspartate...
全文获取路径: Elsevier  (合作)
影响因子:2.537 (2012)

  • cochlear 蜗状物的
  • chinchilla 灰鼠毛皮
  • carboplatin 卡波铂
  • auditory 听觉的
  • nucleus 晶核
  • anteroventral 前腹的
  • nerve 叶脉
  • amino 氨基
  • aspartate 天冬氨酸盐
  • fluorometric 荧光的