Inhibition of ataxia telangiectasia related-3 (ATR) improves therapeutic index in preclinical models of non-small cell lung cancer (NSCLC) radiotherapy
作者: Victoria DunneMihaela GhitaDonna M. SmallCaroline B.M. CoffeySinead WeldonClifford C. TaggartSarah O. OsmanConor K. McGarryKevin M. PriseGerard G. HannaKarl T. Butterworth
作者单位: 1Centre for Cancer Research and Cell Biology, Queen’s University Belfast, UK
2Centre for Experimental Medicine, Queen’s University Belfast, UK
3Northern Ireland Cancer Centre, Queen’s University Belfast, UK
刊名: Radiotherapy and Oncology, 2017
来源数据库: Elsevier Journal
DOI: 10.1016/j.radonc.2017.06.025
关键词: Ataxia telangiectasia related-3 (ATR)AZD6738DNA damage responseNon-small cell lung cancer (NSCLC)FibrosisSmall animal radiotherapy research platform (SARRP)
英文摘要: Abstract(#br)Background and purpose(#br)To evaluate the impact of ATR inhibition using AZD6738 in combination with radiotherapy on the response of non-small cell lung cancer (NSCLC) tumour models and a murine model of radiation induced fibrosis.(#br)Materials and methods(#br)AZD6738 was evaluated as a monotherapy and in combination with radiation in vitro and in vivo using A549 and H460 NSCLC models. Radiation induced pulmonary fibrosis was evaluated by cone beam computed tomography (CBCT) and histological staining.(#br)Results(#br)AZD6738 specifically inhibits ATR kinase and enhanced radiobiological response in NSCLC models but not in human bronchial epithelial cells (HBECs) in vitro . Significant tumour growth delay was observed in cell line derived xenografts (CDXs) of H460 cells ( p...
全文获取路径: Elsevier  (合作)
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影响因子:4.52 (2012)

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关键词翻译
关键词翻译
  • radiotherapy 放射线疗法
  • telangiectasia 毛细管扩张
  • therapeutic 治疗的
  • preclinical 临证前期的
  • ataxia 运动失调
  • ATR Answer Time Recorder
  • cancer 癌症
  • platform 台地
  • related 有关的
  • small 小的