Monomeric CXCL12 outperforms its dimeric and wild type variants in the promotion of human endothelial progenitor cells’ function
作者: Shuang ChangYaning LiFang YuanMeijie QuYaying SongZhijun ZhangGuo-Yuan YangYongting Wang
作者单位: 1Neuroscience and Neuroengineering Research Center, Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China
2Department of Neurology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China
3Department of Neurosurgery, Stanford University School of Medicine, MSLS Building, P306, 1201 Welch Road, Room P306, Stanford, CA 94305, USA
刊名: Biochemical and Biophysical Research Communications, 2017
来源数据库: Elsevier Journal
DOI: 10.1016/j.bbrc.2017.03.172
关键词: CXCL12CXCR4CXCR7Endothelial progenitor cellsMonomer
原始语种摘要: Abstract(#br)CXCL12 overexpression improves neurobehavioral recovery during post-ischemic stroke through multiple mechanisms including promoting endothelial progenitor cells function in animal models. It has been proposed that the monomer and dimer forms possess differential chemotactic and regulatory function. The aim of present study is to explore whether a monomeric or dimeric CXCL12 plays a different role in the endothelial progenitor cells proliferation, migration, and tube-formation in vitro . In this study, we transferred monomeric, dimeric and wild type CXCL12 gene into endothelial progenitor cells via lentiviral vectors. We investigated endothelial progenitor cells function following the interaction of CXCL12/CXCR4 or CXCL12/CXCR7 and downstream signaling pathways. Our results...
全文获取路径: Elsevier  (合作)

  • dimeric 二聚的
  • function 函数
  • promotion 升级
  • human 人的
  • cells 麻风细胞
  • progenitor 祖先
  • endothelial 内皮的