Progesterone receptors, their isoforms and progesterone regulated transcription
作者: Britta M. JacobsenKathryn B. Horwitz
作者单位: 1Department of Medicine/Endocrinology, University of Colorado Anschutz Medical Campus, Mail Stop 8106, Aurora, CO 80045, United States
刊名: Molecular and Cellular Endocrinology, 2012, Vol.357 (1-2), pp.18-29
来源数据库: Elsevier Journal
DOI: 10.1016/j.mce.2011.09.016
关键词: Progesterone receptorTranscriptionMonomerProgesteroneGene regulationIsoform
英文摘要: Abstract(#br)This review discusses mechanisms by which progesterone receptors (PR) regulate transcription. We examine available data in different species and tissues regarding: (1) regulation of PR levels; and (2) expression profiling of progestin-regulated genes by total PRs, or their PRA and PRB isoforms. (3) We address current views about the composition of progesterone response elements, and postulate that PR monomers acting through “half-site” elements are common, entailing cooperativity with neighboring DNA-bound transcription factors. (4) We summarize transcription data for multiple progestin-regulated promoters as directed by total PR, or PRA vs. PRB. We conclude that current models and methods used to study PR function are problematical, and recommend that future work employ...
全文获取路径: Elsevier  (合作)
分享到:
来源刊物:
影响因子:4.039 (2012)

×
关键词翻译
关键词翻译
  • progesterone 孕酮
  • transcription 地名转写
  • regulated 规定
  • regulation 
  • their 他们的