An in vitro evaluation of the efficacy of tedizolid: implications for the treatment of skin and soft tissue infections
作者: Pierre DelpechMuna ALeryanBrian JonesCurtis GemmellSue Lang
作者单位: 1Department of Life Sciences, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, G4 0BA, UK
2Consultant Medical Microbiologist and Head of Microbiology, NHS Greater Glasgow and Clyde, Glasgow Royal Infirmary, 84 Castle Street, Glasgow, G4 0SF, UK
3Division of Infection, Immunity and Inflammation, University of Glasgow, University Avenue, Glasgow, G12 8QQ
刊名: Diagnostic Microbiology & Infectious Disease, 2018, Vol.91 (1), pp.93-97
来源数据库: Elsevier Journal
DOI: 10.1016/j.diagmicrobio.2018.01.006
关键词: Skin and soft tissue infectionsTedizolidLinezolidStaphylococcusBiofilmMinimum inhibitory concentration
英文摘要: Abstract(#br)Skin and soft tissue infections (SSTI) are among the most commonly occurring infections and evidence suggests that these are increasing world-wide. The aetiology is diverse, but Staphylococcus aureus predominate and these are often resistant to antimicrobials that were previously effective. Tedizolid is a new oxazolidinone-class antibacterial indicated for the treatment of adults with SSTI caused by Gram-positive pathogens, including S. aureus . The aim of this study was to evaluate the in vitro efficacy of tedizolid in comparison to other clinically used antibacterials against antibiotic sensitive- and resistant-staphylococci, grown in planktonic cultures and as biofilms reflecting the growth of the microorganism during episodes of SSTI. Against a panel of 66 clinical...
全文获取路径: Elsevier  (合作)

  • efficacy 效验
  • tissue 组织
  • inhibitory 禁止的
  • concentration 浓度
  • Skin 皮肤
  • treatment 处理
  • vitro 体外
  • evaluation 评价