Cannabinoids for spasticity due to multiple sclerosis or paraplegia: a systematic review and meta-analysis of randomized clinical trials
作者: Victoria P. RovareGabriel P.A. MagalhãesGuilherme D.A. JardiniMatheus B. LaverdiMariel GameiroArnav AgarwalGustavo LuvizuttoLucas Paula-RamosSamira Esteves Afonso CamargoLuciane Dias de OliveiraRodrigo BazanRegina El Dib
作者单位: 1São Paulo State University (Unesp), Botucatu Medical School, São Paulo, Brazil
2Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada
3Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
4São Paulo State University (Unesp), Department of Neurology, Botucatu Medical School, Brazil
5São Paulo State University (Unesp), Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo, Brazil
6São Paulo State University (Unesp), Department of Anesthesiology, São Paulo, Brazil
7McMaster Institute of Urology, McMaster University, St. Joseph’s Healthcare, Hamilton, Canada
刊名: Complementary Therapies in Medicine, 2017
来源数据库: Elsevier Journal
DOI: 10.1016/j.ctim.2017.08.010
关键词: cannabinoidsspasticitymultiple sclerosisparaplegia
原始语种摘要: Abstract(#br)Objectives(#br)Spasticity remains highly prevalent in patients with spinal cord injury and multiple sclerosis. To summarize the effects of cannabinoids compared with usual care, placebo for spasticity due to multiple sclerosis (MS) or paraplegia.(#br)Methods(#br)Searches of MEDLINE, EMBASE, CENTRAL and LILACS to March 2017 were performed to identify randomized controlled trials. The primary outcomes were spasticity and spasm frequency. The criteria were any patient with MS and spasticity affecting upper or lower limbs or both, and that had a confirmed diagnosis of MS based on validated criteria, or however defined by the authors of the included studies.(#br)Results(#br)16 trials including 2,597 patients were eligible. Moderate-certainty evidence suggested a non-statistically...
全文获取路径: Elsevier  (合作)
影响因子:2.093 (2012)

  • paraplegia 截瘫
  • spasticity 痉挛状态
  • sclerosis 硬化
  • somnolence 恍惚
  • dizziness 头晕
  • nausea 恶心
  • adverse 逆的
  • multiple 多次的
  • events 定时
  • review 复审