CNS-active drugs in aging population at high risk of cerebrovascular events: Evidence from preclinical and clinical studies
作者: Chuan-Sheng ZhaoSirpa HartikainenTimothy SchallertJuhani SiveniusJukka Jolkkonen
作者单位: 1Department of Neurology, University of Kuopio, Kuopio, Finland
2Department of Neurology, 1st Affiliated Hospital, China Medical University, China
3Division of Geriatrics, Department of Geriatrics, School of Public Health and Clinical Nutrition General Practice, University of Kuopio, Kuopio, Finland
4Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
5Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA
6Department of Neurology, University Hospital of Kuopio and Brain Research and Rehabilitation Center Neuron, Kuopio, Finland
刊名: Neuroscience and Biobehavioral Reviews, 2007, Vol.32 (1), pp.56-71
来源数据库: Elsevier Journal
DOI: 10.1016/j.neubiorev.2007.05.003
关键词: AgingCognitive functionsCerebrovascular eventsFunctional recoveryMedicationSensorimotor impairment
原始语种摘要: Abstract(#br)The recovery process following cerebral insults such as stroke is affected by aging and pharmacotherapy. The use of medication including CNS-active drugs has increased in the elderly during recent years. However, surprisingly little is known about how safe they are with respect to severity of sensorimotor and cognitive impairments or recovery of function following possible cerebrovascular accidents. This review examines the experimental and clinical literature, primarily from 1995 onwards, concerning medication in relation to cerebrovascular events and functional recovery. Special attention is directed to polypharmacy and to new CNS-active drugs, which the elderly are already taking or are prescribed to treat emerging, stroke-induced psychiatric symptoms. The neurobiological...
全文获取路径: Elsevier  (合作)
影响因子:9.44 (2012)

  • events 定时
  • aging 老化
  • polypharmacy 多药疗法
  • drugs 药品
  • sensorimotor 感觉运动的
  • stroke 笔划
  • impairment 减损
  • medication 药疗法
  • preclinical 临证前期的
  • elderly 上了年纪的