Y chromosome loss is a frequent early event in urothelial bladder cancer
作者: Sarah MinnerAdisa KilguéPhillip StahlSteffen WeikertMichael RinkRoland DahlemMargit FischWolfgang HöppnerWalter WagnerCarsten BokemeyerLuigi TerraccianoRonald SimonGuido SauterWaldemar Wilczak
作者单位: 1Institute of Pathology, University Medical Center Hamburg-Eppendorf, Germany
2Department of Urology, University Medical Center Hamburg-Eppendorf, Germany
3Department of Oncology, Hematology, Bone Marrow Transplantation with Section Pneumology, University Medical Center Hamburg-Eppendorf, Germany
4Department of Urology, Charité-University Medicine Berlin, Berlin, Germany
5;Department of Urology, Clinical Center Itzehoe, Itzehoe, Germany
6;Department of Urology, German Armed Forces Hospital, Hamburg, Germany
7;Institute of Pathology, University of Basel, Switzerland
刊名: Pathology, 2010, Vol.42 (4), pp.356-359
来源数据库: Elsevier Journal
DOI: 10.3109/00313021003767298
关键词: Urothelial bladder cancerbladder cancerY chromosome losscytogeneticsurology
原始语种摘要: Summary(#br)Aims(#br)Y chromosome losses have been described in 10-40% of bladder cancers and were suggested to be age-related. The clinical significance of chromosome Y losses is largely unknown, since only small sets of male bladder cancer patients have been evaluated in previous studies. The aim of this study was to further clarify the potential relevance of Y chromosome losses in bladder cancer with respect to clinical outcome and patient age.(#br)Methods(#br)A pre-existing bladder cancer tissue microarray (TMA) with clinical follow-up data including 516 urothelial bladder cancers from male patients was utilised in this study. Y chromosome losses were analysed by multicolour fluorescence in situ hybridisation (FISH) using a centromere Y probe and a centromere X probe. p53...
全文获取路径: Elsevier  (合作)
影响因子:2.657 (2012)

  • bladder 膀胱
  • chromosome 染色体
  • frequent 时常的
  • losses 损耗
  • cancer 癌症
  • event 事件
  • urology 泌尿科学
  • survival 生存
  • centromere 着丝粒
  • increased 增加