Increased sensitivity to vincristine of MDR cells by the leukotriene D 4 receptor antagonist, ONO-1078
作者: Shuichi NagayamaZhe-Sheng ChenMasaki KitazonoYuji TakebayashiKiyoshi NiwaKazutaka YamadaAyako TaniMisako HaraguchiTomoyuki SumizawaTatsuhiko FurukawaTakashi AikouShin-ichi Akiyama
作者单位: 1The Institute for Cancer Research, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, Japan
2The First Department of Surgery, Faculty of Medicine, Kagoshima University, Kagoshima, Japan
刊名: Cancer Letters, 1998, Vol.130 (1), pp.175-182
来源数据库: Elsevier Journal
DOI: 10.1016/S0304-3835(98)00132-3
关键词: VincristineMDR cellsONO-1078
原始语种摘要: Abstract(#br)The leukotriene D 4 (LTD 4 ) receptor antagonist, 4-oxo-8-[ p -(4-phenylbutyloxy)benzoylamino]-2-(tetrazol-5-yl)-4H-1-benzopyran hemihydrate (ONO-1078) is used for the treatment of allergic asthma and other immediate hypersensitivity diseases. We examined the effect of ONO-1078 on the sensitivity to vincristine (VCR) of MRP overexpressing multidrug-resistant CV60 and its parental drug-sensitive KB-3-1 cell lines. The sensitivity to VCR of KB-3-1 and CV60 cells was increased 13- and 15-fold, respectively, by ONO-1078 at the maximum non-toxic concentration (100 μ M). The VCR sensitivity of multidrug-resistant KB-C2 cells that overexpressed P-gp was increased 2.6-fold by ONO-1078. The accumulation of VCR in KB-3-1, CV60 and KB-C2 cells was significantly increased by ONO-1078....
全文获取路径: Elsevier  (合作)
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影响因子:4.258 (2012)

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关键词翻译
关键词翻译
  • leukotriene 白细胞三烯
  • cells 麻风细胞
  • sensitivity 灵敏度
  • vincristine 长春新碱
  • VCR Video Cassette Recorder
  • increased 增加
  • antagonist 对抗剂
  • asthma 哮喘
  • allergic 变应性的
  • receptor 接受体