Association of plasma-soluble ST2 and galectin-3 with cardiovascular events and mortality following cardiac surgery
作者: Dipal M. PatelHeather Thiessen-PhilbrookJeremiah R. BrownEric McArthurDennis G. MoledinaSherry G. MansourMichael G. ShlipakJay L. KoynerPeter KavsakRichard P. WhitlockAllen D. EverettDavid J. MalenkaAmit X. GargSteven G. CocaChirag R. Parikh
作者单位: 1Program of Applied Translational Research, Department of Medicine, Yale University School of Medicine, New Haven, CT
2Division of Nephrology, School of Medicine, Johns Hopkins University, Baltimore, MD
3Dartmouth Institute for Health Policy and Clinical Practice, and the Departments of Biomedical Data Science and Epidemiology, Geisel School of Medicine, Lebanon, NH
4ICES, Toronto, ON, Canada
5Section of Nephrology, Yale University School of Medicine, New Haven, CT
6Kidney Health Research Collaborative, University of California San Francisco, San Francisco, CA
7Department of Medicine, San Francisco VA Medical Center and University of California, San Francisco, CA
8Section of Nephrology, Department of Medicine, University of Chicago, Pritzker School of Medicine, Chicago, IL
9Departments of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada
10Population Health Research Institute and Department of Surgery, McMaster University, Hamilton, ON, Canada
11Division of Cardiology, Department of Ped
刊名: American Heart Journal, 2020, Vol.220 , pp.253-263
来源数据库: Elsevier Journal
DOI: 10.1016/j.ahj.2019.11.014
原始语种摘要: Background(#br)Cardiac surgery induces hemodynamic stress on the myocardium, and this process can be associated with significant post-operative morbidity and mortality. Soluble suppression of tumorigenicity 2 (sST2) and galectin-3 (gal-3) are biomarkers of myocardial remodeling and fibrosis; however, their potential association with post-operative changes is unknown.(#br)Methods(#br)We measured peri-operative plasma sST2 and gal-3 levels in two prospective cohorts (TRIBE-AKI and NNE) of over 1800 patients who underwent cardiac surgery. sST2 and gal-3 levels were evaluated for association with a composite primary outcome of cardiovascular event or mortality over median follow-up periods of 3.4 and 6.0 years, respectively, for the two cohorts. Meta-analysis of hazard ratio estimates from...
全文获取路径: Elsevier  (合作)
影响因子:4.497 (2012)

  • Association 美国公共卫生协会
  • events 定时
  • following 追踪
  • cardiac 贲门
  • mortality 死亡率
  • plasma 深绿玉髓
  • soluble 可溶的
  • surgery 外科
  • cardiovascular 心血管的