Altered Gene and Protein Expressions in Torn Rotator Cuff Tendon Tissues in Diabetic Patients
作者: Seok Won ChungBo Mi ChoiJa Yeon KimYong-Soo LeeJong Pil YoonKyung-Soo OhKyung Sik Park
作者单位: 1Department of Orthopaedic Surgery, Konkuk University School of Medicine, Seoul, Republic of Korea
2Korea University College of Medicine, Seoul, Republic of Korea
刊名: Arthroscopy: The Journal of Arthroscopic and Related Surgery, 2016
来源数据库: Elsevier Journal
DOI: 10.1016/j.arthro.2016.08.017
原始语种摘要: Purpose(#br)To analyze and compare the gene and protein expression characteristics in torn rotator cuff tendon tissues between diabetic and nondiabetic patients.(#br)Methods(#br)This was a pilot study. Twelve samples of rotator cuff tendon tissue from diabetic patients (mean age, 62.3 ± 9.9 years) and 12 age- and sex-matched nondiabetic tendon tissues (62.3 ± 9.9 years) were acquired from the torn tendon end of medium rotator cuff tears during arthroscopic surgery, after applying the same inclusion and exclusion criteria. Expressions of various genes of interest, including collagens I and III, matrix metalloprotease (MMP)-2, MMP-3, MMP-9, MMP-13, interleukin (IL)-1, IL-6, insulin-like growth factor-1, vascular endothelial growth factor, tenomodulin, tumor necrosis factor-α, and p53, were...
全文获取路径: Elsevier  (合作)