Transneuronal spread of Semliki Forest virus in the developing mouse olfactory system is determined by neuronal maturity
作者: K.R OliverJ.K Fazakerley
作者单位: 1Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QP, UK
刊名: Neuroscience, 1997, Vol.82 (3), pp.867-877
来源数据库: Elsevier Journal
DOI: 10.1016/S0306-4522(97)00309-6
关键词: olfactory systemalphavirusneurovirulenceneuronal maturation
原始语种摘要: Abstract(#br)Many neurotropic virus infections have been shown to be virulent in neonatal and suckling mice but avirulent in weaned mice. The neurotropic alphavirus Semliki Forest virus is a well-studied example of this and importantly the age-related change in neurovirulence of this virus has been shown to be independent of specific immune responses. During the first two postnatal weeks many major physiological changes including axonogenesis, synaptogenesis and myelination occur within the rodent CNS. To investigate whether these changes affect virus replication, spread and virulence we have studied the course of infection in the mouse olfactory system. The olfactory system is well-characterized with regard to its development and neuroanatomy and represents an important route of entry of...
全文获取路径: Elsevier  (合作)
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影响因子:3.122 (2012)

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关键词翻译
关键词翻译
  • olfactory 嗅觉的
  • virus 病毒
  • neurotropic 亲神经的
  • spread 散布
  • neuronal 二乙基溴乙酰胺
  • neurovirulence 神经毒力
  • myelination 髓鞘生成
  • infection 感染
  • maturation 成熟
  • postnatal 出生后的