Extended Versus Limited Lymph Node Dissection in Bladder Cancer Patients Undergoing Radical Cystectomy: Survival Results from a Prospective, Randomized Trial▪
作者: Jürgen E. GschwendMatthias M. HeckJan LehmannHerbert RübbenPeter AlbersJohannes M. WolffDetlef FrohnebergPatrick de GeeterAxel HeidenreichTilman KälbleMichael StöckleThomas SchnöllerArnulf StenzlMarkus MüllerMichael TrussStephan RothUwe-Bernd LiehrJoachim LeißnerThomas BregenzerMargitta Retz
作者单位: 1Department of Urology, Rechts der Isar Medical Center, Technical University of Munich, Munich, Germany
2AUO Study Group, Germany
3Department of Urology, University of Essen, Germany
4Department of Urology, Heinrich Heine University, Düsseldorf, Germany
5Department of Urology, Paracelsus Hospital Golzheim Düsseldorf, Düsseldorf, Germany
6Department of Urology, Hospital of Karlsruhe, Germany
7Department of Urology, Hospital of Kassel, Germany
8Department of Urology, University of Cologne, Cologne, Germany
9Department of Urology, Hospital of Fulda, Germany
10Department of Urology, Saarland University Medical Center, Homburg, Germany
11Department of Urology, Ulm University, Germany
12Department of Urology, Eberhard Karls University, Tübingen, Germany
13Department of Urology, Hospital Ludwigshafen, Germany
14Department of Urology, Hospital Dortmund, Germany
15Department of Urology, Helios Hospital, Wuppertal, Germany
16Department of Urology, Otto von Guericke University, Magdeburg, Germany
17Department of Urology, Hospita
刊名: European Urology, 2019, Vol.75 (4), pp.604-611
来源数据库: Elsevier Journal
DOI: 10.1016/j.eururo.2018.09.047
关键词: Bladder cancerCancer-specific survivalCystectomyLymph node dissectionRecurrence-free survivalOverall survival
原始语种摘要: Abstract(#br)Background(#br)The extent of lymph node dissection (LND) in bladder cancer (BCa) patients at the time of radical cystectomy may affect oncologic outcome.(#br)Objective(#br)To evaluate whether extended versus limited LND prolongs recurrence-free survival (RFS).(#br)Design, setting, and participants(#br)Prospective, multicenter, phase-III trial patients with locally resectable T1G3 or muscle-invasive urothelial BCa (T2-T4aM0).(#br)Intervention(#br)Randomization to limited (obturator, and internal and external iliac nodes) versus extended LND (in addition, deep obturator, common iliac, presacral, paracaval, interaortocaval, and para-aortal nodes up to the inferior mesenteric artery).(#br)Outcome measurements and statistical analysis(#br)The primary endpoint was RFS. Secondary...
全文获取路径: Elsevier  (合作)
影响因子:10.476 (2012)

  • survival 生存
  • cystectomy 膀胱切除术
  • extended 扩展
  • Cancer 巨蟹座
  • bladder 膀胱
  • resectable 可切除的
  • lymph 淋巴
  • recurrence 循环
  • trial 试验
  • resection 后方交会