Preparation and characterization of bioadhesive system containing hypericin for local photodynamic therapy
作者: Fernanda Belincanta Borghi-PangoniMariana Volpato JunqueiraSabrina Barbosa de Souza FerreiraLarissa Lachi SilvaBruno Ribeiro RabelloLidiane Vizioli de CastroMauro Luciano BaessoAndréa DinizWilker CaetanoMarcos Luciano Bruschi
作者单位: 1Postgraduate Program in Pharmaceutical Sciences, Laboratory of Research and Development of Drug Delivery Systems, Department of Pharmacy, State University of Maringá, Maringá, Paraná, Brazil
2Postgraduate Program in Chemistry, Department of Chemistry, State University of Maringá, Maringá, Paraná, Brazil
3Department of Physics, State University of Maringá, Maringá, Paraná, Brazil
刊名: Photodiagnosis and Photodynamic Therapy, 2017, Vol.19 , pp.284-297
来源数据库: Elsevier Journal
DOI: 10.1016/j.pdpdt.2017.06.016
关键词: Biodegradable polymersHypericinPhotodynamic therapyBiological evaluationNatural productsPhysicochemical properties
原始语种摘要: Abstract(#br)Hypericin (Hyp) is a natural photoactive pigment utilized in the treatment of different types of cancer and antimicrobial inactivation using photodynamic therapy (PDT). Hyp is poorly soluble in water leading to problems of administration, getting close contact with the site, and bio-availability. Therefore, this study aimed to develop bioadhesive thermoresponsive system containing Hyp for local PDT. Carbomer 934P, poloxamer 407, and Hyp were used to prepare the thermoresponsive bioadhesive formulations. They were characterized for sol-gel transition temperature, mechanical, mucoadhesive, rheological (continuous flow and oscillatory) and dielectric properties, syringeability, in vitro Hyp release kinetics, ex vivo permeability, and photodynamic activity. The formulations...
全文获取路径: Elsevier  (合作)
影响因子:2.243 (2012)

  • photodynamic 在光中发荧光的
  • system 
  • permeate 渗透
  • containing 包含的
  • properties 道具
  • hypericin 金丝桃蒽酮
  • kinetics 动力学
  • suitable 合适的
  • biological 生物学的
  • availability 有效度