Bull sperm acrosome reaction induced by gamma-aminobutyric acid (GABA) is mediated by GABAergic receptors type A
作者: M.A. PuenteC.M. TartaglioneM.N. Ritta
作者单位: 1School of Agrarian Sciences. University of Lomas de Zamora, Buenos Aires, Argentina
2CONICET Argentina
刊名: Animal Reproduction Science, 2011, Vol.127 (1), pp.31-37
来源数据库: Elsevier Journal
DOI: 10.1016/j.anireprosci.2011.07.001
关键词: Bull spermAcrosome reactionGABA A receptorGABACalcium channelCl − channel
原始语种摘要: Abstract(#br)The effect of gamma-aminobutyric acid (GABA) on the bull sperm acrosome reaction was evaluated, and the interaction of progesterone, a physiologic inducer of the acrosome reaction, with the GABA receptor was explored. The acrosome reaction was stimulated by GABA in a dose-dependent manner. This effect was inhibited completely by bicuculline, a GABA A receptor antagonist, but GABA B and C receptor antagonists had no effect. Accordingly, muscimol, a GABA A receptor agonist, stimulated the acrosome reaction to the same extent as GABA, whereas baclofen (GABA B receptor agonist) and CACA (GABA C receptor agonist), had no effect. Preincubation with progesterone followed by the addition of GABA resulted in a significant increase in the percentage of acrosome reacted spermatozoa...
全文获取路径: Elsevier  (合作)
影响因子:1.897 (2012)

  • GABA 伽马氨基丁酸
  • acrosome 顶体
  • sperm 精子
  • reaction 反酌
  • receptor 接受体
  • gamma 伽马
  • progesterone 孕酮
  • induced 感应的
  • picrotoxin 苦毒
  • bicuculline 荷包牡丹碱