Transcriptomics investigation of thyroid hormone disruption in the olfactory system of the Rana [Lithobates] catesbeiana tadpole
作者: Kevin W. JackmanNik VeldhoenRachel C. MilianoBonnie J. RobertLinda LiAzadeh KhojastehXiaoyu ZhengTristan S.M. ZaborniakGraham van AggelenMary LesperanceWayne J. ParkerEric R. HallGregory G. PyleCaren C. Helbing
作者单位: 1Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, V8P 5C2, Canada
2Environment and Climate Change Canada, Pacific Environmental Science Centre, 2645 Dollarton Highway, North Vancouver, British Columbia, V7H 1V2, Canada
3Department of Mathematics and Statistics, University of Victoria, Victoria, British Columbia, V8P 5C2, Canada
4Department of Civil and Environmental Engineering, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada
5Department of Civil Engineering, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada
6Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, T1K 3M4, Canada
刊名: Aquatic Toxicology, 2018, Vol.202 , pp.46-56
来源数据库: Elsevier Journal
DOI: 10.1016/j.aquatox.2018.06.015
关键词: Olfactory systemEndocrine disruptionAmphibianFrogThyroid hormoneMunicipal wastewater treatmentPharmaceuticals and personal care productsGene expressionEstrogenTranscriptomicsPostembryonic development
原始语种摘要: Abstract(#br)Thyroid hormones (THs) regulate vertebrate growth, development, and metabolism. Despite their importance, there is a need for effective detection of TH-disruption by endocrine disrupting chemicals (EDCs). The frog olfactory system substantially remodels during TH-dependent metamorphosis and the objective of the present study is to examine olfactory system gene expression for TH biomarkers that can evaluate the biological effects of complex mixtures such as municipal wastewater. We first examine classic TH-response gene transcripts using reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR) in the olfactory epithelium (OE) and olfactory bulb (OB) of premetamorphic Rana (Lithobates) catesbeiana tadpoles after 48 h exposure to biologically-relevant...
全文获取路径: Elsevier  (合作)
影响因子:3.73 (2012)

  • olfactory 嗅觉的
  • wastewater 废水
  • tadpole 蝌蚪
  • biological 生物学的
  • disruption 破裂
  • removal 消去
  • hormone 激素
  • system 
  • treatment 处理
  • bioreactor 生物反应器