Multicentric Standardized Flow Cytometry Routine Assessment of Patients With Sepsis to Predict Clinical Worsening
作者: Thomas DaixEstelle GuerinElsa TavernierEmmanuelle MercierValérie GissotOlivier HéraultJean-Paul MiraFlorence DumasNicolas ChapuisChristophe GuittonMarie C. BénéJean-Pierre QuenotCindy TissierJulien GuyGaël PitonAnne RoggyGrégoire MullerÉric LegacNicolas de ProstMehdi KhellafOrianne Wagner-BallonRémi CoudroyElodie DindinaudFabrice UhelMikaël RousselThomas LafonRobin JeannetFrédéric VargasCatherine FleureauMickaël RouxKaoutar AllouPhilippe Vignon
作者单位: 1Réanimation Polyvalente, CHU Dupuytren, Limoges
2Inserm CIC1435, CHU Dupuytren, Limoges
3Hématologie Biologique, CHU Dupuytren, Limoges
4CNRS UMR 7276, Université de Limoges, Limoges
5Inserm CIC1415, CHRU and Université François Rabelais, Tours
6Réanimation Polyvalente, CHRU de Tours, Tours
7Hématologie Biologique, CHRU de Tours, Tours
8Réanimation Médicale Polyvalente, Hôpital Cochin, Assistance Publique des Hôpitaux de Paris, Paris
9Urgences, Hôpital Cochin/Hôtel-Dieu, Assistance Publique des Hôpitaux de Paris and Inserm UMR 970, Université Paris Descartes, Paris
10Hématologie Biologique, Hôpital Cochin, Assistance Publique des Hôpitaux de Paris, Paris
11Réanimation Médicale and Inserm UMR1064, CHU de Nantes, Nantes
12Hématologie Biologique, CHU de Nantes, Nantes
13Réanimation Polyvalente, CHU François Mitterrand and Lipness Team, Centre de Recherche Inserm LNC-UMR1231 and LabExLipSTIC and Inserm CIC 1432, Epidémiologie Clinique, Université de Bourgogne, Dijon
14Urgences, CHU de Dijon, Dijon
15Hématologie Biologi
刊名: Chest, 2018
来源数据库: Elsevier Journal
DOI: 10.1016/j.chest.2018.03.058
关键词: Flow cytometryImmunosuppressionInflammationPrognosisSepsis
英文摘要: Background(#br)In this study, we primarily sought to assess the ability of flow cytometry to predict early clinical deterioration and overall survival in patients with sepsis admitted in the ED and ICU.(#br)Methods(#br)Patients admitted for community-acquired acute sepsis from 11 hospital centers were eligible. Early (day 7) and late (day 28) deaths were notified. Levels of CD64 pos granulocytes, CD16 pos monocytes, CD16 dim immature granulocytes (IGs), and T and B lymphocytes were assessed by flow cytometry using an identical, cross-validated, robust, and simple consensus standardized protocol in each center.(#br)Results(#br)Among 1,062 patients screened, 781 patients with confirmed sepsis were studied (age, 67 ± 48 years; Simplified Acute Physiology Score II, 36 ± 17; Sequential Organ...
全文获取路径: Elsevier  (合作)
影响因子:5.854 (2012)