Sodium tungstate induced neurological alterations in rat brain regions and their response to antioxidants
作者: Sherry SachdevaSatish C. PantPramod KushwahaRakesh BhargavaSwaran J.S. Flora
作者单位: 1Division of Regulatory Toxicology, Defence Research and Development Establishment, Gwalior, Madhya Pradesh, India
刊名: Food and Chemical Toxicology, 2015, Vol.82 , pp.64-71
来源数据库: Elsevier Journal
DOI: 10.1016/j.fct.2015.05.003
关键词: Sodium tungstate toxicityOxidative stressAntioxidantsFlavonoidsBrain regionsNeurotoxicity
原始语种摘要: Abstract(#br)Tungsten, recognized recently as an environmental contaminant, is being used in arms and ammunitions as substitute to depleted uranium. We studied the effects of sodium tungstate on oxidative stress, few selected neurological variables like acetylcholinesterase, biogenic amines in rat brain regions (cerebral cortex, hippocampus and cerebellum) and their prevention following co-administration of N-acetylcysteine (NAC), naringenin and quercetin. Animals were sub-chronically exposed to sodium tungstate (100 ppm in drinking water) and orally co-supplemented with different antioxidants (0.30 mM) for three months. Sodium tungstate significantly decreased the activity of acetylcholinesterase, dopamine, nor-epinephrine and 5-hydroxytryptamine levels while it increased monoamine...
全文获取路径: Elsevier  (合作)
影响因子:3.01 (2012)

  • induced 感应的
  • brain 
  • antioxidants 抗氧化剂
  • tungstate 钨酸盐
  • cortex 皮层
  • oxidative 氧化的
  • variables 变量
  • stress 应力
  • administration 管理
  • acetylcysteine 乙酰半胱胺酸