Hydrogen sulfide protects neonatal rat medulla oblongata against prenatal cigarette smoke exposure via anti-oxidative and anti-inflammatory effects
作者: Xiang YanFang LeiYajie HuLihong NieQingyi JiaHua ZhouFusheng ZhaoYu Zheng
作者单位: 1Department of Physiology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, 610041 Sichuan, PR China
2Department of Physiology, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004 Ningxia, PR China
刊名: Environmental Toxicology and Pharmacology, 2018, Vol.57 , pp.151-158
来源数据库: Elsevier Journal
DOI: 10.1016/j.etap.2017.12.009
关键词: Hydrogen sulfidePrenatal cigarette smoke exposureMedulla oblongataAnti-oxidative effectAnti-inflammatory effect
原始语种摘要: Abstract(#br)We previously demonstrated that hydrogen sulfide (H 2 S) protected neonatal rat medulla oblongata from prenatal cigarette smoke exposure (CSE) via anti-apoptotic effect. The present work further investigated the involvement of anti-oxidative and anti-inflammatory effects of H 2 S in the protection. Pregnant Sprague-Dawley rats were randomly divided into NaCl, CSE, CSE + NaHS (a donor of H 2 S) and NaHS groups. All the tests were performed with corresponding neonatal rats. Nissl staining revealed that NaHS treatment ameliorated neuronal chromatolysis in the hypoglossal nucleus and nucleus ambiguus resulted from prenatal CSE. Moreover, NaHS eliminated decrease of glutathione level, increase of malondialdehyde content and inhibition of superoxide dismutase activity within...
全文获取路径: Elsevier  (合作)
影响因子:2.005 (2012)

  • prenatal 产前的
  • neonatal 新生儿的
  • oxidative 氧化的
  • cigarette 香烟
  • medulla 骨髓
  • exposure 暴露
  • inflammatory 激怒的
  • against 反对
  • smoke 灰云
  • hypoglossal 舌下的