Experimental and modelling characterisation of adjustable hollow Micro-needle delivery systems
作者: Ting-Ting LiuKai ChenMin Pan
作者单位: 1School of Mechanical Engineering, Hangzhou Dianzi University, Hangzhou, Zhejiang 310018, China
刊名: Medical Engineering and Physics, 2017
来源数据库: Elsevier Journal
DOI: 10.1016/j.medengphy.2017.08.012
关键词: Hollow micro-needleResistance pressureDrug delivery
原始语种摘要: Abstract(#br)Background(#br)Hollow micro-needles have been used increasingly less in practice because the infusion into the skin is limited by the tissue resistance to flow. The relationship between the infusion flow rate and tissue resistance pressure is not clear.(#br)Methods(#br)A custom-made, hollow micro-needle system was used in this study. The driving force and infusion flow rate were measured using a force transducer attached to an infusion pump. Evans blue dye was injected into the air, polyacrylamide gel and in-vivo mouse skin at different flow rates. Two different micro-needle lengths were used for in-vivo infusion into the mouse. A model was derived to calculate the driving force of the micro-needle infusion into the air, and the results were compared to experimental...
全文获取路径: Elsevier  (合作)
影响因子:1.779 (2012)

  • increasingly 愈加
  • driving 传动的
  • system 
  • resistance 抵抗
  • needle 针叶
  • modelling 模型制造
  • micro 
  • calculate 计算
  • infusion 浸剂
  • backflow 逆流回流