Analysis of Molecular Recognition Features (MoRFs)
作者: Amrita MohanChristopher J. OldfieldPredrag RadivojacVladimir VacicMarc S. CorteseA. Keith DunkerVladimir N. Uversky
作者单位: 1School of Informatics, Indiana University, Bloomington, IN 47408, USA
2Center for Computational Biology and Bioinformatics, Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
3Molecular Kinetics, Inc., Indianapolis, IN 46268, USA
4Institute for Biological Instrumentation, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia
刊名: Journal of Molecular Biology, 2006, Vol.362 (5), pp.1043-1059
来源数据库: Elsevier Journal
DOI: 10.1016/j.jmb.2006.07.087
关键词: intrinsic disordermolecular recognitionPONDRsignalingprotein–protein interaction
原始语种摘要: Abstract(#br)Several proteomic studies in the last decade revealed that many proteins are either completely disordered or possess long structurally flexible regions. Many such regions were shown to be of functional importance, often allowing a protein to interact with a large number of diverse partners. Parallel to these findings, during the last five years structural bioinformatics has produced an explosion of results regarding protein–protein interactions and their importance for cell signaling. We studied the occurrence of relatively short (10–70 residues), loosely structured protein regions within longer, largely disordered sequences that were characterized as bound to larger proteins. We call these regions molecular recognition features (MoRFs, also known as molecular recognition...
全文获取路径: Elsevier  (合作)
影响因子:3.905 (2012)

  • Recognition 识别
  • recognition 识别
  • protein 蛋白质
  • intrinsic 内倌
  • disorder 无序
  • flexible 接电绳
  • database 资料库
  • importance 重要性
  • Analysis 分析
  • features 特征