Important role of Maillard reaction in the protective effect of heat-processed ginsenoside Re-serine mixture against cisplatin-induced nephrotoxicity in LLC-PK1 cells
作者: Ji Hwan LeeWoojung LeeSeungyong LeeYujung JungSoon-Hye ParkPilju ChoiSu-Nam KimJungyeob HamKi Sung Kang
作者单位: 1Natural Medicine Center, Korea Institute of Science and Technology, Gangneung 210-340, Republic of Korea
刊名: Bioorganic & Medicinal Chemistry Letters, 2012, Vol.22 (17), pp.5475-5479
来源数据库: Elsevier Journal
DOI: 10.1016/j.bmcl.2012.07.018
关键词: Maillard reactionGinsenoside ReOxidative stressNephrotoxicityHeat-processing
原始语种摘要: Abstract(#br)The aim of the present study was to verify the important role of Maillard reaction in the protective effect of heat-processed ginsenoside Re-serine mixture against oxidative stress-induced nephrotoxicity. The free radical-scavenging activity of ginsenoside Re-serine mixture was increased by heat-processing. Ginsenoside Re was transformed into less-polar ginsenosides such as Rg 2 , Rg 6 and F 4 by heat-processing, and the glucose molecule at carbon-20 was separated. The improved-free radical-scavenging activity by heat-processing was mediated by the generation of antioxidant Maillard reaction products (MRPs) from the reaction of glucose with serine. Moreover, MRPs from ginsenoside Re-serine mixture showed protective effect against cisplatin-induced renal epithelial cell damage.
全文获取路径: Elsevier  (合作)
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来源刊物:
影响因子:2.338 (2012)

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关键词翻译
关键词翻译
  • reaction 反酌
  • nephrotoxicity 中毒性肾损害
  • ginsenoside 人参皂甙
  • cisplatin 顺氯氨铂
  • mixture 混合物
  • serine 丝氨酸
  • processing 加工
  • effect 效应
  • induced 感应的
  • against 反对