Proliferation markers predictive of the pathological response and disease outcome of patients with breast carcinomas treated by anthracycline-based preoperative chemotherapy
作者: Anne Vincent-SalomonAlexandra RousseauMichel JouvePhilippe BeuzebocBrigitte Sigal-ZafraniPaul FréneauxChristophe RostyClaude NosFrançois CampanaJerzy KlijanienkoAbir Al GhuzlanXavier Sastre-Garau
作者单位: 1Department of Pathology, Institut Curie, Paris, France
2Department of Biostatistics, Institut Curie, Paris, France
3Department of Oncology, Institut Curie, Paris, France
4Department of Surgery, Institut Curie, Paris, France
5Department of Radiotherapy, Institut Curie, Paris, France
刊名: European Journal of Cancer, 2004, Vol.40 (10), pp.1502-1508
来源数据库: Elsevier Journal
DOI: 10.1016/j.ejca.2004.03.014
关键词: Preoperative chemotherapyMitotic indexPredictive markersProliferation markersPrognostic markersPathological response
原始语种摘要: Abstract(#br)The cell proliferation rate has been correlated to the response of breast carcinomas to preoperative chemotherapy (CT) and to disease outcome. However, this parameter is not yet used to select which tumours should be treated with preoperative CT. Furthermore, there is no consensus in the method used to evaluate cell proliferation. In poor prognosis breast carcinomas (PPBCs) treated by intensive preoperative CT, we compared the predictive value of S phase fraction (SPF), mitotic index (MI) and Ki67. We also evaluated the prognostic significance of the variation of the MI after CT. A series of 55 T2-T4N0N1M0 breast carcinomas were treated with 4 cycles of cyclophosphamide, 5-fluorouracil (5-FU) and doxorubicin. SPF was determined by flow cytometry on pre-therapeutic needle...
全文获取路径: Elsevier  (合作)
影响因子:5.061 (2012)

  • preoperative 操作前的
  • chemotherapy 化学疗法
  • breast 胸部
  • predictive 预言
  • treated 加工的
  • markers 时标
  • pathological 病理学的
  • outcome 效果
  • response 响应
  • therapeutic 治疗的