Genome-wide association study identifies polymorphisms associated with the analgesic effect of fentanyl in the preoperative cold pressor-induced pain test
作者: Kaori TakahashiDaisuke NishizawaShinya KasaiYoshihiko KoukitaKen-ichi FukudaTatsuya IchinoheKazutaka Ikeda
作者单位: 1Department of Dental Anesthesiology, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan
2Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan
3Division of Special Needs Dentistry and Orofacial Pain, Department of Oral Health and Clinical Science, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan
刊名: Journal of Pharmacological Sciences, 2018, Vol.136 (3), pp.107-113
来源数据库: Elsevier Journal
DOI: 10.1016/j.jphs.2018.02.002
关键词: Opioid sensitivityAnalgesiaFentanylPolymorphismGWAS
英文摘要: Abstract(#br)Opioid analgesics are widely used for the treatment of moderate to severe pain. The analgesic effects of opioids are well known to vary among individuals. The present study focused on the genetic factors that are associated with interindividual differences in pain and opioid sensitivity. We conducted a multistage genome-wide association study in subjects who were scheduled to undergo mandibular sagittal split ramus osteotomy and were not medicated until they received fentanyl for the induction of anesthesia. We preoperatively conducted the cold pressor-induced pain test before and after fentanyl administration. The rs13093031 and rs12633508 single-nucleotide polymorphisms (SNPs) near the LOC728432 gene region and rs6961071 SNP in the tcag7.1213 gene region were significantly...
全文获取路径: Elsevier  (合作)
影响因子:2.15 (2012)

  • fentanyl 芬太尼
  • analgesic 镇痛药
  • preoperative 操作前的
  • effect 效应
  • induced 感应的
  • pressor 增压剂
  • association 联合
  • associated 相关的
  • study 学习