Functional microglia neurotransmitters in amyotrophic lateral sclerosis
作者: Cinzia VolontéSusanna AmadioPaola FabbrizioSavina Apolloni
作者单位: 1CNR, Institute of Cell Biology and Neurobiology, Largo Francesco Vito 1, 00168, Rome, Italy
2Fondazione Santa Lucia IRCCS, Preclinical Neuroscience, Via Del Fosso di Fiorano 64, 00143, Rome, Italy
3Department of Systems Medicine, Tor Vergata University, Via Montpellier 1, 00133, Rome, Italy
刊名: Seminars in Cell and Developmental Biology, 2019, Vol.94 , pp.121-128
来源数据库: Elsevier Journal
DOI: 10.1016/j.semcdb.2019.04.014
关键词: ALSExtracellular ATPGlutamateHistamineMicrogliaSOD1-G93A
原始语种摘要: Abstract(#br)Today neuroscience is dominated by the perspective that microglia are essential elements in any integrated view of the nervous system. A number of different neuroinflammatory conditions affect the CNS where microglia involvement, and particularly microgliosis, is not only a prominent feature, but also a pathogenic key mechanism of disease. On the other side, microglia can also constitute an important trigger of neuronal protection during neurodegenerative disorders. For instance in ALS and other motor neuron diseases, available evidence suggests the coexistence of quite different roles for microglia, characterized by neuroprotective functions at early stages, and neurotoxic actions during disease progression. The scope of this review is a brief discussion about microglia...
全文获取路径: Elsevier  (合作)
影响因子:6.202 (2012)

  • 神经的 特别
  • microglia 小神经胶质细胞
  • amyotrophic 肌肉萎缩的
  • ALS Accumulator Left Shift
  • sclerosis 硬化
  • neuroscience 神经学
  • neurotoxic 神经中毒的
  • histamine 组胺
  • particularly 特别
  • nervous 特别
  • discussion 讨论