Expression, mutational analysis and in vitro response of imatinib mesylate and nilotinib target genes in ovarian granulosa cell tumors
作者: Simon ChuMaria AlexiadisPeter J. Fuller
作者单位: 1Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia
刊名: Gynecologic Oncology, 2007, Vol.108 (1), pp.182-190
来源数据库: Elsevier Journal
DOI: 10.1016/j.ygyno.2007.09.017
关键词: Tyrosine kinasec-kitc-AblPlatelet-derived growth factor receptorsOvarian cancer
原始语种摘要: Abstract(#br)Objectives.(#br)Granulosa cell tumors of the ovary (GCT) represent ∼5% of malignant ovarian tumors. Surgery remains the primary modality of therapy and treatment options for advanced disease are limited. The molecular pathogenesis of GCT is not known but is likely to involve activation of tyrosine kinase-mediated cell signaling pathways. A recent case report of a patient with advanced recurrent GCT responding to the tyrosine kinase inhibitor, imatinib mesylate prompted us to explore a role for these therapies in GCT.(#br)Methods.(#br)The expression of the imatinib-sensitive tyrosine kinases, c-kit, c-Abl, PDGFR-α and PDGFR-β, was determined using RT–PCR in a panel of GCT. Activating mutations of c-kit and PDGFR-α were also sought. The functional response...
全文获取路径: Elsevier  (合作)
影响因子:3.929 (2012)

  • target 目标
  • ovarian 卵巢的
  • mesylate 甲磺酸盐
  • unlikely 不可能的
  • GCT Graphics Communications Terminal
  • inhibitor 抑制剂
  • tyrosine 酪氨酸
  • functional 功能的
  • vitro 体外
  • observed 观察到的