Oleanane-type triterpenoid saponins from Lysimachia fortunei Maxim
作者: Shu-Lin ZhangZi-Ni YangCui HeHai-Bing LiaoHeng-Shan WangZhen-Feng ChenDong Liang
作者单位: 1State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, People's Republic of China
刊名: Phytochemistry, 2018, Vol.147 , pp.140-146
来源数据库: Elsevier Journal
DOI: 10.1016/j.phytochem.2017.12.022
关键词: Lysimachia fortunei MaximMyrsinaceaeTriterpenoid saponinsCytotoxic activities
英文摘要: Abstract(#br)Six previously undescribed oleanane-type triterpenoid saponins, fortunosides A–F, together with six known ones, were isolated from the aerial parts of L ysimachia fortunei Maxim. Their structures were established by spectroscopic data analyses (1D, 2D-NMR and HRESIMS) and chemical methods. All isolated triterpenoid saponins were evaluated for their cytotoxicity against four human liver cancer cell lines (SMMC-7721, Hep3B, HuH7, and SK-Hep-1). Three saponins with the aglycone protoprimulagenin A exhibited moderate cytotoxicity against all of the tested human cancer cell lines, with IC 50 values ranging from 4.76 to 15.12 μM.
全文获取路径: Elsevier  (合作)
影响因子:3.05 (2012)

  • saponins 皂甙
  • triterpenoid 三萜系化合物