Chitosan-DNA polyelectrolyte complex: Influence of chitosan characteristics and mechanism of complex formation
作者: Lourdes Mónica Bravo-AnayaKarla Gricelda Fernández-SolísJulien RosselgongJesrael Luz Elena Nano-RodríguezFrancisco CarvajalMarguerite Rinaudo
作者单位: 1Universidad de Guadalajara, Departamento de Ingeniería Química, Blvd. M. García Barragán #1451, 44430 Guadalajara, Jalisco, Mexico
2University of Bordeaux/Bordeaux INP, ENSCBP and CNRS, Laboratoire de Chimie des Polymères Organiques (UMR5629), 16 avenue Pey-Berland, Pessac 33607, France
3Centro Universitario UTEG, Departamento de Investigación, Héroes Ferrocarrileros #1325, Guadalajara, Jalisco 44460, Mexico
4CUTonalá, Departamento de Ingenierías, Universidad de Guadalajara, Nuevo Periférico # 555 Ejido San José Tatepozco, 45425, Jalisco, Mexico
5Biomaterials Applications, 6 rue Lesdiguières, 38000 Grenoble, France
刊名: International Journal of Biological Macromolecules, 2019
来源数据库: Elsevier Journal
DOI: 10.1016/j.ijbiomac.2019.01.008
关键词: Polyelectrolyte complexesDNA-chitosan complexElectrostatic interactionDNA compaction
英文摘要: Abstract(#br)Polyelectrolyte complexes formed between DNA and chitosan present different and interesting physicochemical properties combined with high biocompatibility; they are very useful for biomedical applications. DNA in its double helical structure is a semi-rigid polyelectrolyte chain. Chitosan, an abundant polysaccharide in nature, is considered as one of the most attractive vectors due to its biocompatibility and biodegradability. Here we study chitosan/DNA polyelectrolyte complex formation mechanism and the key factors of their stability. Compaction process of DNA with chitosan was monitored in terms of the ζ-potential and hydrodynamic radius variation as a function of charge ratios between chitosan and DNA. The influence of chitosan degree of acetylation (DA) and its molecular...
全文获取路径: Elsevier  (合作)

  • complex 超群
  • chitosan 壳聚糖
  • formation 建造
  • mechanism 机构
  • DNA Deoxyribonucleic Acid
  • compaction 压缩
  • interaction 相互酌