Potential antidiabetic zinc(II) complexes of novel 5-oxo-2-thioxopyrrolidine derivatives synthesized via an unprecedented reaction
作者: Saya KawanoYutaka YoshikawaAkihiro KatoShoko HigashiKyohei MitaniHiroyuki YasuiYoichi HabataShunsuke KuwaharaKaname SasakiRyota Saito
作者单位: 1Department of Chemistry, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan
2Department of Health, Sports and Nutrition, Kobe Women’s University, 4-7-2 Minatojima-nakamachi, Chuo-ku, Kobe 650-0046, Japan
3Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan
4Research Center for Materials with Integrated Properties, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan
刊名: Tetrahedron Letters, 2019, Vol.60 (23), pp.1534-1537
来源数据库: Elsevier Journal
DOI: 10.1016/j.tetlet.2019.05.001
关键词: 5-Oxo-2-thioxopyrrolidineZinc(II) complexInsulin-mimetic activityAntidiabetic agent
英文摘要: Abstract(#br)We have developed a synthetic route to novel ethyl 1-arylmethyl-5-oxo-2-thioxopyrrolidine-3-carboxylates ( 1a – e ) via an unprecedented reaction of ethyl 1-arylmethyl-4-acetoxy-5-oxo-2,5-dihydro-1 H -pyrrole-3carboxylates with potassium thioacetate. Synthesized products 1a – e were further converted into their zinc(II) complexes ( 10a – e ), having an S 2 O 2 -type coordination mode, that showed improved insulin-mimetic activities compared to ZnSO 4 , a positive standard, and also the previously reported zinc(II) complexes of ethyl 1-benzyl-4-hydroxy-5-oxo-2,5-dihydro-1 H -pyrrole-3-carboxylates with O 4 -type coordination mode.
全文获取路径: Elsevier  (合作)
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影响因子:2.397 (2012)

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关键词翻译
关键词翻译
  • antidiabetic 治糖尿[病]药
  • II Interactive Interface
  • mimetic 模仿的
  • novel 长篇小说
  • unprecedented 前所未有的
  • reaction 反酌
  • complexes 联合企业
  • derivatives 派生物
  • activity 活度
  • agent 因子