[ 18 F]DPA-714, [ 18 F]PBR111 and [ 18 F]FEDAA1106—Selective radioligands for imaging TSPO 18<ce:hsp sp="0.25"/>kDa with PET: Automated radiosynthesis on a TRACERLAb FX-FN synthesizer and quality controls
作者: Bertrand KuhnastAnnelaure DamontFrançoise HinnenTony CatarinaStéphane DemphelStéphane Le HelleixChristine CoulonSébastien GoutalPhilippe GervaisFrédéric Dollé
作者单位: 1CEA, I2BM, Service Hospitalier Frédéric Joliot, 4 Place du Général Leclerc, F-91401, Orsay Cedex, France
刊名: Applied Radiation and Isotopes, 2011, Vol.70 (3), pp.489-497
来源数据库: Elsevier Journal
DOI: 10.1016/j.apradiso.2011.10.015
关键词: Fluorine-18TRACERlab FX-FNTSPO 18kDa[ 18 F]DPA-714[ 18 F]FEDAA1106[ 18 F]PBR111
原始语种摘要: Abstract(#br)Imaging of TSPO 18kDa with PET is more and more considered as a relevant biomarker of inflammation in numerous diseases. Development of new radiotracers for TSPO 18kDa has seen acceleration in the last years and the challenge today is to make available large amounts of such a radiotracer in compliance with GMP standards for application in humans. We present in this technical note automated productions of [ 18 F]DPA-714, [ 18 F]PBR111 and [ 18 F]FEDAA1106, three promising radiotracers for TSPO 18kDa imaging, using a TRACERlab FX-FN synthesizer. This note also includes the quality control data of the validation batches for the manufacturing qualification of clinical production of [ 18 F]DPA-714.
全文获取路径: Elsevier  (合作)
影响因子:1.179 (2012)

  • quality 品质
  • DPA Data Processing Area
  • synthesizer 合成器
  • control 控制
  • technical 技术的
  • standards 规程
  • imaging 图像形成
  • radiosynthesis 辐射合成
  • three 
  • years 年代