Clinicopathological significance of tumor cyclin D1 expression in oral cancer
作者: Pablo Ramos-GarcíaMiguel Ángel González-MolesLucía González-RuizÁngela AyénIsabel Ruiz-ÁvilaManuel BravoJosé Antonio Gil-Montoya
作者单位: 1School of Dentistry, University of Granada, Granada, Spain
2Instituto de Investigación Biosanitaria, Granada, Spain
3Servicio de Dermatología, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
4School of Medicine, University of Granada, Granada, Spain
5Servicio de Anatomía Patológica, Complejo Hospitalario Universitario de Granada, Granada, Spain
刊名: Archives of Oral Biology, 2019, Vol.99 , pp.177-182
来源数据库: Elsevier Journal
DOI: 10.1016/j.archoralbio.2019.01.018
关键词: Cyclin D1CCND1Oral carcinogenesisOralCancer
原始语种摘要: Abstract(#br)Objective(#br)To evaluate the association of cyclin D1 overexpression with clinicopathological parameters classically considered of prognostic value in OSCC (T, N, M, clinical stage, degree of differentiation, invasive morphology and, cellular proliferation index).(#br)Design(#br)A retrospective immunohistochemical study was conducted of cyclin D1 and ki-67 expression in 68 OSCCs from 54 patients. Cases were scanned using a digital pathology system. The tumor expression of markers was assessed in four randomly selected fields (40x), and a semi-automatized count was conducted of cyclin D1-positive and -negative cells.(#br)Results(#br)Cyclin D1 overexpression was found in 28.7% of the cases of OSCC. It was significantly and positively associated with the following...
全文获取路径: Elsevier  (合作)
影响因子:1.549 (2012)

  • cyclin 细胞周期蛋白
  • carcinogenesis 癌形成
  • expression 表示
  • tumor 肿胀
  • significance 显著性
  • prognosis 预报
  • cancer 癌症
  • invasive 侵入的
  • associated 相关的
  • parameters 参数