Fish oil supplementation of maternal rats on an n-3 fatty acid-deficient diet prevents depletion of maternal brain regional docosahexaenoic acid levels and has a postpartum anxiolytic effect
作者: Hui-Feng ChenHui-Min Su
作者单位: 1Department of Physiology, National Taiwan University College of Medicine, Taipei, Taiwan
刊名: The Journal of Nutritional Biochemistry, 2012, Vol.23 (3), pp.299-305
来源数据库: Elsevier Journal
DOI: 10.1016/j.jnutbio.2010.12.010
关键词: Docosahexaenoic acidArachidonic acidSerotoninFish oilReproductive cycleAnxiety
原始语种摘要: Abstract(#br)Docosahexaenoic acid (DHA) and arachidonic acid (AA) are the major polyunsaturated fatty acids (PUFA) in the neuronal membrane. Most DHA and AA accumulation in the brain occurs during the perinatal period via placenta and milk. This study examined whether maternal brain levels of DHA and AA are depleted during pregnancy and lactation due to meeting the high demand of the developing nervous system in the offspring and evaluated the effects of the reproductive cycle on serotonin metabolism and of fish oil (FO) on postpartum anxiety. Pregnant rats were fed during pregnancy and lactation with a sunflower oil-based n-3 PUFA-deficient diet without or with FO supplementation, which provided 0.37% of the energy source as n-3 PUFA, and the age-matched virgin rats were fed the same...
全文获取路径: Elsevier  (合作)
影响因子:4.552 (2012)

  • 额骨 脂肪的
  • maternal 母的
  • anxiolytic 抗焦虑药
  • postpartum 产后的
  • brain 
  • depletion 矿量递减
  • serotonin 血清素
  • effect 效应
  • hypothalamus 丘脑下部
  • fatty 脂肪的
  • frontal 脂肪的