Taxane Resistance in Prostate Cancer Mediated by AR-Independent GATA2 Regulation of IGF2
作者: Stephen R. PlymateRupal S. BhattSteven P. Balk
作者单位: 1Department of Medicine, University of Washington and GRECC-VAPSHCS, Seattle, WA 98104, USA
2Division of Hematology-Oncology, Department of Medicine, Beth Israel Deaconess Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
刊名: Cancer Cell, 2015, Vol.27 (2), pp.158-159
来源数据库: Elsevier Journal
DOI: 10.1016/j.ccell.2015.01.008
原始语种摘要: GATA2 has been well-characterized as a critical pioneer transcription factor for androgen receptor (AR) in prostate cancer. In this issue of Cancer Cell , Vidal and colleagues identify increased GATA2 and its AR-independent transactivation of IGF2 as a mechanism that can mediate taxane resistance through activation of IGF1/insulin receptor signaling.
全文获取路径: Elsevier  (合作)
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影响因子:24.755 (2012)

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关键词翻译
关键词翻译
  • receptor 接受体
  • transcription 地名转写
  • androgen 雄激素
  • mediate 
  • insulin 胰岛素
  • prostate 前列腺
  • activation 活化
  • signaling 发信号
  • independent 独立的
  • Cancer 巨蟹座