Asymmetrical proliferative pattern loss linked to cyclin D1 overexpression in adjacent non-tumour epithelium in oral squamous cell carcinoma
作者: Pablo Ramos-GarcíaMiguel Ángel González-MolesÁngela AyénLucía González-RuizIsabel Ruiz-ÁvilaDaniel LenouvelJosé Antonio Gil-MontoyaManuel Bravo
作者单位: 1School of Dentistry, University of Granada, Granada, Spain
2Instituto de Investigación Biosanitaria, Granada, Spain
3School of Medicine, University of Granada, Granada, Spain
4Servicio de Dermatología, Hospital General Universitario de Ciudad Real, Ciudad Real, Spain
5Servicio de Anatomía Patológica, Complejo Hospitalario Universitario de Granada, Granada, Spain
刊名: Archives of Oral Biology, 2019, Vol.97 , pp.12-17
来源数据库: Elsevier Journal
DOI: 10.1016/j.archoralbio.2018.10.007
关键词: Cyclin D1CCND1Oral cancerPremalignant fields
原始语种摘要: Abstract(#br)Objective(#br)To evaluate cyclin D1 overexpression in oral squamous cell carcinomas and adjacent non-tumour epithelium as a biomarker of premalignant fields and a risk factor for multiple tumour development.(#br)Design(#br)We studied cyclin D1 expression in 54 patients with 68 oral squamous cell carcinomas plus adjacent non-tumour epithelia characterized as close (n = 58) or distant (n = 41) from the invasion point. Randomized 40x fields were evaluated (4 in tumour tissue and 1 each in close and distant non-tumour epithelium). Expression in non-tumour epithelium was evaluated in basal, parabasal, middle-third and upper-third compartments.(#br)Results(#br)Cyclin D1 overexpression was found in both carcinomas and non-tumour epithelia. Nuclear expression in basal and parabasal...
全文获取路径: Elsevier  (合作)
影响因子:1.549 (2012)

  • tumour 肿瘤
  • cyclin 细胞周期蛋白
  • squamous 具鳞的
  • epithelia 上皮细胞
  • distant 远离的
  • epithelium 上皮
  • premalignant 恶变前的
  • adjacent 相邻的
  • significantly 较大地
  • carcinogenesis 癌形成