Sulfation pattern of chondroitin sulfate in human osteoarthritis cartilages reveals a lower level of chondroitin-4-sulfate
作者: Tzung-Sheng LinChang-Hsun HsiehChin KuoYu-Pu JuangYves S.Y. HsiehHongsen ChiangShang-Cheng HungChing-Chuan JiangPi-Hui Liang
作者单位: 1School of Pharmacy, College of Medicine, National Taiwan University, Taipei, 100, Taiwan
2Genomics Research Center, Academia Sinica, Taipei, 128, Taiwan
3Department of Orthopedic Surgery, National Taiwan University Hospital, National Taiwan University, Taipei, 100, Taiwan
4Department of Radiation Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
5Division of Glycoscience, Department of Chemistry, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology (KTH), Stockholm, SE106 91, Sweden
刊名: Carbohydrate Polymers, 2020, Vol.229
来源数据库: Elsevier Journal
DOI: 10.1016/j.carbpol.2019.115496
关键词: Chondroitin sulfateSulfotransferaseSulfataseOsteoarthritisAdult cartilage
原始语种摘要: Abstract(#br)Chondroitin sulfates (CS) account for more than 80% of the glycosaminoglycans of articular cartilage, which impart its physiological functions. We quantified the absolute concentration of the CS components of the full thickness cartilages from the knees of patients with terminal-phase osteoarthritis. Osteochondrol biopsies were removed from the medial femoral condyle and lateral femoral condyle of sixty female patients received total knee arthroplasty, aged from 58 to 83 years old. We found the total CS concentrations and chondroitin-4-sulfate disaccharide were significantly lowered in osteoarthritic samples. Microstructure analysis indicated while chondroitin-0-sulfate was equally distributed across different zones of the osteoarthritic cartilages, chondroitin-4-sulfate is...
全文获取路径: Elsevier  (合作)
影响因子:3.479 (2012)

  • sulfate 硫酸盐
  • chondroitin 软骨碱
  • osteoarthritis 骨关节炎
  • concentrations 浓聚物
  • femoral 股的
  • responsible 负责的
  • sulfation 硫酸化
  • cartilage 软骨
  • arthroplasty 关节成形术
  • articular 关节的