Genetic variants of TNFα , IL10 , IL1β , CTLA4 and TGFβ1 modulate the indices of alcohol-induced liver injury in East Indian population
作者: Neelanjana RoyIndranil MukhopadhyayKausik DasPratap PanditPartha P. MajumderAmal SantraSimanti DattaSoma BanerjeeAbhijit Chowdhury
作者单位: 1Centre for Liver Research, Institute of Post Graduate Medical Education & Research, Kolkata, India
2Human Genetics Unit, Indian Statistical Institute, Kolkata, India
3National Institute of Biomedical Genomics, Kalyani, India
刊名: Gene, 2012, Vol.509 (1), pp.178-188
来源数据库: Elsevier Journal
DOI: 10.1016/j.gene.2012.07.077
关键词: Alcoholic liver diseaseTNFαIL10IL1βTGFβ1Polymorphism
原始语种摘要: Abstract(#br)Alcohol induced liver disease or alcoholic liver disease (ALD), a complex trait, encompasses a gamut of pathophysiological alterations in the liver due to continuous exposure to a toxic amount of alcohol (more than 80g per day). Of all chronic heavy drinkers, only 15–20% develops hepatitis or cirrhosis concomitantly or in succession. Several studies revealed that inter-individual as well as inter-ethnic genetic variation is one of the major factors that predispose to ALD. The role of genetic factors in ALD has long been sought for in ethnically distinct population groups. ALD is fast emerging as an important cause of chronic liver disease in India; even in populations such as “Bengalis” who were “culturally immune” earlier. While the genetic involvement in...
全文获取路径: Elsevier  (合作)
影响因子:2.196 (2012)

  • liver 
  • genetic 遗传的
  • population 母体
  • alcohol 
  • distinct 相异的
  • allelic 等位的
  • ALD Analog Line Driver
  • induced 感应的
  • Bengali 孟加拉人
  • genotype 属型