Intravenous thrombolysis with tissue-plasminogen activator in small vessel occlusion
作者: Young Min PaekJi Sung LeeHong-Kyun ParkYong-Jin ChoHee-Joon BaeBeom Joon KimJong-Moo ParkSoo Joo LeeJae-Kwan ChaTai Hwan ParkKyung Bok LeeJun LeeByung-Chul LeeJoon-Tae KimDong-Eog KimDong-Ick ShinWook-Joo KimSung-Il SohnJay Chol ChoiKeun-Sik Hong
作者单位: 1Department of Neurology, Ilsan Paik Hospital Inje University, Goyang, Republic of Korea
2Clinical Research Center, Asan Medical Center, Seoul, Republic of Korea
3Department of Neurology, Seoul National University, Bundang Hospital, Seongnam, Republic of Korea
4Department of Neurology, Eulji General Hospital, Seoul, Republic of Korea
5Department of Neurology, Eulji University Hospital, Daejeon, Republic of Korea
6Department of Neurology, Dong-A University Hospital, Busan, Republic of Korea
7Department of Neurology, Seoul Medical Center, Seoul, Republic of Korea
8Department of Neurology, Soonchunhyang University Hospital Seoul, Seoul, Republic of Korea
9Department of Neurology, Yeungnam University Medical Center, Daegu, Republic of Korea
10Department of Neurology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea
11Department of Neurology, Chonnam National University Hospital, Gwangju, Republic of Korea
12Department of Neurology, Dongguk University Ilsan Hospital, Goyang, Republic of Korea
刊名: Journal of Clinical Neuroscience, 2019, Vol.64 , pp.134-140
来源数据库: Elsevier Journal
DOI: 10.1016/j.jocn.2019.03.036
关键词: Intravenous thrombolysisTissue-plasminogen activatorSmall vessel occlusionSubgroup analysis
英文摘要: Abstract(#br)Intravenous tissue-plasminogen activator (IV-TPA) treatment in acute ischemic stroke (AIS) patients due to small vessel occlusion (SVO) has been debated because of its small expected benefit and symptomatic intracranial hemorrhage (SICH) risk. Furthermore, data on subgroups of SVO patients are limited. From a prospective multicenter stroke registry database, AIS patients due to SVO within 24 h from onset were selected. Efficacy outcomes were 3-month modified Rankin Scale (mRS) score 0–1 proportion and mRS score distribution. Additionally, subgroup analyses were conducted by age, sex, initial National Institute Health Stroke Scale (NIHSS) score, and presenting limb paresis. This study included 2482 patients: 193 in the IV-TPA group and 2289 in the control group. After...
全文获取路径: Elsevier  (合作)
影响因子:1.253 (2012)

  • plasminogen 胞浆素原
  • thrombolysis 血栓溶解
  • occlusion 锢囚
  • activator 活化剂
  • vessel 容器
  • tissue 组织
  • analysis 分析
  • small 小的