The expression of IL10RA in colorectal cancer and its correlation with the proliferation index and the clinical stage of the disease
作者: Łukasz ZadkaMichał J. KulusKrzysztof KurnolAleksandra PiotrowskaNatalia Glatzel-PlucińskaTomasz JurekMagdalena CzubaAleksandra NowakMariusz ChabowskiDariusz JanczakPiotr Dzięgiel
作者单位: 1Department of Human Morphology and Embryology, Wroclaw Medical University, Wroclaw, Poland
2II Department of Psychiatry and Psychiatric Rehabilitation, Medical University of Lublin, Lublin, Poland
3Department of Forensic Medicine, Wroclaw Medical University, Wroclaw, Poland
4Surgical Clinic, 4th Military Hospital in Wroclaw, Poland
刊名: Cytokine, 2018, Vol.110 , pp.116-125
来源数据库: Elsevier Journal
DOI: 10.1016/j.cyto.2018.04.030
关键词: IL10RAKi67IL10STAT3Colorectal cancer
英文摘要: Abstract(#br)Introduction(#br)Despite the widely described role of IL10 in immune response regulation during carcinogenesis, there is no established model describing the role of its receptor. The aim of this study is to elucidate the relationship between the subunit alpha of IL10 receptor (IL10RA) in the pathogenesis of colorectal cancer (CRC).(#br)Methods(#br)The study was conducted on archived paraffin blocks of 125 CRC patients, from which tissue microarrays (TMA) were made. These were subsequently used for immunohistochemistry to assess the expression of IL10RA, IL10, phosphorylated STAT3 (pSTAT3) and the Ki67 proliferation index. The intensity of both reactions was assessed by independent researchers using two approaches: digital image analysis and the Remmele and Stegner score...
全文获取路径: Elsevier  (合作)
影响因子:2.518 (2012)

  • colorectal 结肠直肠的
  • correlation 对比
  • cancer 癌症
  • expression 表示
  • stage 
  • proliferation 增生
  • STAT 静止的
  • index 指标
  • clinical 临床的
  • disease