Relationships among genotypes, virulence and clinical forms of Sporothrix schenckii infection
作者: X. KongT. XiaoJ. LinY. WangH.-D. Chen
作者单位: 1Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang 110001, China
刊名: Clinical Microbiology and Infection, 2006, Vol.12 (11), pp.1077-1081
来源数据库: Elsevier Journal
DOI: 10.1111/j.1469-0691.2006.01519.x
关键词: Clinical formsmiceRAPD typingSporothrix schenckiitypingvirulence
原始语种摘要: ABSTRACT(#br)This study explored the relationships among genotypes, virulence and clinical forms of Sporothrix schenckii . Genomic DNA from isolates of S. schenckii , collected from different clinical forms of sporotrichosis, was amplified by randomly amplified polymorphic DNA (RAPD). Suspensions of different isolates of S. schenckii were inoculated into healthy BALB/c mice to compare their virulence, and the numbers and distribution of spores were determined by histological analysis. RAPD analysis indicated that the isolates from different clinical forms of sporotrichosis belonged to different genotypes. The mice inoculated with isolates from disseminated sporotrichosis showed an earlier onset of illness and more severe lesions than those inoculated with isolates from lymphocutaneous...
全文获取路径: Elsevier  (合作)

  • sporotrichosis 孢子丝菌病
  • disseminated 浸染的
  • forms 格式
  • isolates 单离体
  • virulence 病毒性
  • inoculated 接种过的
  • infection 感染
  • clinical 临床的
  • typing 打字
  • polymorphic 多形