Histamine beyond its effects on allergy: Potential therapeutic benefits for the treatment of Amyotrophic Lateral Sclerosis (ALS)
作者: Cinzia VolontéSavina ApolloniMario Sabatelli
作者单位: 1CNR-Institute of Cell Biology and Neurobiology/UCSC, Largo Francesco Vito 1, 00168 Rome, Italy
2Fondazione Santa Lucia IRCCS, Preclinical Neuroscience, Via Del Fosso di Fiorano 65, 00143 Rome, Italy
3Institute of Neurology-Catholic University of Sacro Cuore, Clinic Center NEMO- Fondazione Pol. A. Gemelli IRCCS, Largo Agostino Gemelli, 8, 00168 Rome, Italy
刊名: Pharmacology and Therapeutics, 2019, Vol.202 , pp.120-131
来源数据库: Elsevier Journal
DOI: 10.1016/j.pharmthera.2019.06.006
关键词: ALSHistamineMicrogliaMotor neuronNeuroinflammationPersonalized medicineSOD1-G93A
原始语种摘要: Abstract(#br)ALS currently remains a challenge despite many efforts in performing successful clinical trials and formulating therapeutic solutions. By learning from current failures and striving for success, scientists and clinicians are checking every possibility to search for missing hints and efficacious treatments. Because the disease is very complex and heterogeneous and, moreover, targeting not only motor neurons but also several different cell types including muscle, glial, and immune cells, the right answer to ALS is conceivably a multidrug strategy or the use of broad-spectrum molecules. The aim of the present work is to gather evidence about novel perspectives on ALS pathogenesis and to present recent and innovative paradigms for therapy. In particular, we describe how an old...
全文获取路径: Elsevier  (合作)
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来源刊物:
影响因子:7.793 (2012)

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关键词翻译
关键词翻译
  • ALS Accumulator Left Shift
  • allergy 变应性
  • therapeutic 治疗的
  • SOD Superintendent Of Documents
  • benefits 津贴费
  • treatment 处理
  • neuron 神经元
  • medicine 
  • effects 海员自身物品
  • beyond 在...那边