Luteinizing hormone receptors are expressed in rat myenteric neurons and mediate neuronal loss
作者: Elin SandUlrikke VossBodil OhlssonEva Ekblad
作者单位: 1Department of Experimental Medical Science, Unit Neurogastroenterology, BMC B11, Lund University, Sölvegatan 19, SE 22184 Lund, Sweden
2Department of Clinical Sciences, Division of Internal Medicine, Lund University, Sweden Lund University, Inga Marie Nilssons gata 32, SE 21428 Malmö, Sweden
刊名: Autonomic Neuroscience: Basic and Clinical, 2015, Vol.193 , pp.104-107
来源数据库: Elsevier Journal
DOI: 10.1016/j.autneu.2015.10.001
关键词: Enteric nervous system (ENS)Gonadotropin-releasing hormone (GnRH)Luteinizing hormonePrimary cultures of enteric neurons
原始语种摘要: Abstract(#br)Background(#br)Clinical observations have suggested repeated gonadotropin-releasing hormone (GnRH) exposure to cause intestinal dysfunction and loss of enteric neurons. This has been further studied and confirmed in a rat in vivo model involving iterated GnRH treatments. Mechanisms behind are enigmatic since no GnRH receptors are found to be expressed in enteric neurons neither in man nor rat. Both species, however, harbor substantial subpopulations of luteinizing hormone (LH) receptor-immunoreactive myenteric neurons which suggests that intestinal GnRH-induced neuropathy may be mediated by LH release.(#br)Aims(#br)To reveal if exposures of GnRH or LH to rat myenteric neurons in vitro cause neuronal loss.(#br)Methods(#br)Primary cultured adult rat myenteric neurons were...
全文获取路径: Elsevier  (合作)
影响因子:1.846 (2012)