Protective effects of M8‑B, a TRPM8 antagonist, on febrile‑ and pentylenetetrazol‑induced seizures
作者: Nazanin Zandi1 Nosaibeh Riahi Zaniani2 Ali Moghimi2 and Ali Roohbakhsh3*
作者单位: 1; e-mail: roohbakhsha@mums.ac.ir1Department of Pharmacodynamics and Toxicology
2 School of Pharmacy
3 Mashhad University of Medical Sciences
4 Mashhad
5 Iran
62Rayan Center for Neuroscience and Behavior
7 Department of Biology
8 Faculty of Science
9 Ferdowsi University of Mashhad
10 3Pharmaceutical Research Center
11 Pharmaceutical Technology Institute
刊名: Acta Neurobiologiae Experimentalis, 2019, Vol.79 (79)
来源数据库: Exeley Inc.
原始语种摘要: Epilepsy is a life‑threatening disorder that is marked by recurrent seizures. Febrile seizure is a common neurological disorder observed in neonates. In many cases, reducing body temperature can prevent febrile seizure. Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a cation channel that is involved in body thermoregulation. It was reported that M8‑B, a TRPM8 antagonist, can reduce body temperature. Thus, we aimed to investigate the effect of M8‑B on different experimental seizure models. Eight‑day‑old male Wistar rat pups were used for induction of febrile seizure. M8‑B and diazepam were injected intraperitoneally. The rat pups were then transferred to a heated plexiglas chamber and the latency to the first febrile seizure was measured. In addition, different...
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影响因子:1.977 (2012)

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关键词翻译
关键词翻译
  • TRPM PLYMOUNTH/BLACKBURNE
  • electroshock 电休克疗法
  • induced 感应的
  • anticonvulsant 镇痉剂
  • effect 效应
  • convulsions 惊厥
  • antagonist 对抗剂
  • latency 潜伏
  • diazepam 安定
  • first 第一