Neuroprotective effects of lipopolysaccharide and naltrexone co‑preconditioning in the photothrombotic model of unilateral selective hippocampal ischemia in rat
作者: Sayed Masoud Hosseini1 Alireza Golaghaei1* Ehsan Nassireslami1 Nima Naderi23 Hamid Gholami Pourbadie4 Milad Rahimzadegan5 and Saeid Mohammadi5
作者单位: 1; e-mail: of Pharmacology and Toxicology
2 School of Medicine
3 AJA University of Medical Sciences
4 Tehran
5 Iran
6 2Department of Pharmacology and Toxicology
7 School of Pharmacy
8 Shahid Beheshti University of Medical Sciences
93Neuroscience Research Center
10 4Department of Physiology and Pharmacology
11 Pasteur Institute of Iran
12 5Department of Pharmacology and Toxicology
13 Tehran University of Medical Sciences
刊名: Acta Neurobiologiae Experimentalis, 2019, Vol.79 (79)
来源数据库: Exeley Inc.
原始语种摘要: Preconditioning with lipopolysaccharide (LPS) or opioid antagonists has a neuroprotective effect in ischemic insults. However, the co‑preconditioning effect of toll‑like receptor ligands and opioid antagonists has not been investigated. In this study we examined the neuroprotective effect of LPS and naltrexone (NTX) preconditioning and co‑preconditioning in unilateral selective hippocampal ischemia in rats to assess for possible synergistic protective effects. LPS and NTX were injected unilaterally into the left cerebral ventricle of male rats. Forty‑eight hours after LPS and twenty‑four hours after NTX injection, ipsilateral selective hippocampal ischemia was induced using a modified version of the photothrombotic method. Protective effects for LPS and NTX were assessed by evaluating...
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影响因子:1.977 (2012)

  • LPS Laboratory Peripheral System
  • naltrexone 纳曲酮
  • effect 效应
  • unilateral 片面的
  • ischemia 局部贫血
  • selective 选择性的
  • infarct 梗塞
  • opioid 鸦片样物质
  • synergistic 协同的
  • impairment 减损